In its journey for reaching the unreached, Indira Gandhi National Open University has established its Regional Centre at Thiruvananthapuram in January 2009. The jurisdiction of the Regional Centre, Trivandrum is Kollam, Pathanamthitta, Thiruvananthapuram districts of Kerala and Kanyakumari district of Tamil Nadu.

As on date Regional Centre, Trivandrum caters to the educational requirements of its jurisdiction through a network of 53 Learner Support Centres, comprising 11 Study Centres, 32 Programme Study Centres and 10 Special Study Centres.